Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption

This guidance document was originally published in 2012 and updated in 2018 to reflect new and updated 蜂鸟电竞在线入口 test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals. The document is intended to provide guidance for evaluating chemical using standardised test guidelines. Specific objectives include providing a description of the 蜂鸟电竞在线入口 conceptual framework for evaluating chemicals for endocrine disruption, background on the standardised test methods used, and guidance for interpreting the outcome of individual tests. The general approach taken by the document is primarily to provide guidance on how test results might be interpreted based on the outcome of standardised assays. Key questions addressed in the document concern likely mechanisms of endocrine action and any resulting apical effects that can be attributed to such action. The document is not proscriptive but provides suggestions for possible next steps in testing (if any) which might be appropriate for a regulatory authority to take, given the various data scenarios. The guidance document is focused primarily on endocrine modalities included in the conceptual framework; estrogen, androgen, and thyroid mediated endocrine disruption and chemicals that interfer with steroidogenesis.

Published on September 03, 2018

In series: 蜂鸟电竞在线入口 Series on Testing and Assessment view more titles


General Guidance on Endocrine Assessment: Assays and Endpoints
Specific guidance for the test guidelines addressed 3 chapters available
Introduction to specific guidelines
蜂鸟电竞在线入口 in vitro screens (Conceptual Framework Level 2)
Non-蜂鸟电竞在线入口 in vitro screens (Conceptual Framework Level 2)
蜂鸟电竞在线入口 non-mammalian screens and tests (Conceptual Framework Levels 3-5) 14 chapters available
Fish Short-Term Reproduction Assay (FSTRA) (蜂鸟电竞在线入口 TG 229)
21-Day Fish Assay (蜂鸟电竞在线入口 TG 230)
Amphibian Metamorphosis Assay (AMA) (蜂鸟电竞在线入口 TG 231)
Potamopyrgus antipodarum Reproduction Test (蜂鸟电竞在线入口 TG 242)
Lymnaea stagnalis Reproduction Test (蜂鸟电竞在线入口 TG 243)
Chironomid Toxicity Test Using Spiked Sediment (蜂鸟电竞在线入口 TG 218) or Spiked Water (蜂鸟电竞在线入口 TG 219)
Daphnia magna Reproduction Test (蜂鸟电竞在线入口 TG 211)
Fish, Early-Life Stage (FELS) Toxicity Test (蜂鸟电竞在线入口 TG 210)
Fish Sexual Development Test (FSDT) (蜂鸟电竞在线入口 TG 234)
Larval Amphibian Growth and Development Assay (LAGDA) (蜂鸟电竞在线入口 TG 241)
Avian Reproduction Test (蜂鸟电竞在线入口 TG 206)
Sediment-Water Chironomid Life-Cycle Toxicity Test (蜂鸟电竞在线入口 TG 233)
Medaka Extended One-Generation Reproduction Test (MEOGRT) (蜂鸟电竞在线入口 TG 240)
Non-蜂鸟电竞在线入口 non-mammalian screens and tests (Conceptual Framework Levels 3-5)
蜂鸟电竞在线入口 mammalian screens and tests (Conceptual Framework Levels 3-5) 16 chapters available
Uterotrophic Bioassay in Rodents (UT assay) (蜂鸟电竞在线入口 TG 440) (including 蜂鸟电竞在线入口 GD 71 on the procedure to test for anti-estrogenicity)
Hershberger Bioassay in Rats (H assay) (蜂鸟电竞在线入口 TG 441) (including 蜂鸟电竞在线入口 GD 115 on the Weanling Hershberger Bioassay)
Repeated Dose 28-Day Oral Toxicity Study in Rodents (蜂鸟电竞在线入口 TG 407)
Repeated Dose 90-Day Oral Toxicity Study in Rodents (蜂鸟电竞在线入口 TG 408)
Combined Chronic Toxicity/Carcinogenicity Studies (蜂鸟电竞在线入口 TG 451-3)
Reproduction/Developmental Toxicity Screening Test (蜂鸟电竞在线入口 TG 421) and Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test (蜂鸟电竞在线入口 TG 422)
Prenatal Developmental Toxicity Study (蜂鸟电竞在线入口 TG 414)
Developmental Neurotoxicity Study (蜂鸟电竞在线入口 TG 426)
Repeated Dose Dermal Toxicity: 21/28-Day Study (蜂鸟电竞在线入口 TG 410)
Subchronic Dermal Toxicity: 90-Day Study (蜂鸟电竞在线入口 TG 411)
28-Day (Subacute) Inhalation Toxicity Study (蜂鸟电竞在线入口 TG 412)
Subchronic Inhalation Toxicity: 90-Day Study (蜂鸟电竞在线入口 TG 413)
Repeated Dose 90-Day Oral Toxicity Study in Non-Rodents (蜂鸟电竞在线入口 TG 409)
Two-Generation Reproduction Toxicity Study (蜂鸟电竞在线入口 TG 416)
Extended One-Generation Reproductive Toxicity Study (EOGRTS) (蜂鸟电竞在线入口 TG 443)
Non-蜂鸟电竞在线入口 mammalian screens and tests (Concptual Framework Levels 3-5)
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